- the number-scales
- experimental techniques
Since most of our discussions will revolve around theory or standard models, the discussion will allow us to understand how one can seek to employ these theories as usable theoretical models by experimental validation or just reasoning through.
- Force spectroscopy of proteins and nucleic acids Cytoskeleton: Actin and microtubules Motor proteins
- Protein diffusion, ligand-receptor binding and crowding effects Biomembrane mechanics
- Red blood cells
- Cell adhesion and migration
- Mechanical forces Mass, stiffness and the damping of proteins
- Thermal forces
- Polymer mechanics
- Molecular motor stepping
- Membrane bending and vesicle formation
- Simplest models of cell shape
Paper reading of biophysical techniques will be evaluated in class.
Additional problem based assignments will intersperse the course. Regular quizzes will be conducted after the conclusion of substantial material. They will be announced and surprise, open- and closed-book.Continuous assessment will constitute half the assessment, the other half being traditional exams.
At the end of the course you should be able to understand and evaluate sensible theoretical models of cell-biological systems from a biophysics perspective. The course will be complementary to Cell Biology (based on the book by B. Alberts et al. Mol. Biol. Cell).
Intructors:
Primary instructor: Dr. Chaitanya Athale (Div. of Biology @iiserpune)
Guest lectures: 2-3 lectures by Dr. Namrata Gundiah, BioEngineering @iisc Bangalore
Assessment: Internal assesment (50%) includes evaluation of assignments, paper-reading and quizzes. Exam based assesment carries the remaining 50% of the score.
Course-Coordinator email: bio322 at the rat e student s dot ii serpune do t a c d o t in
You can also in case of urgent issues email me at cathale at the rate of iiser pune dot academia dot in.