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NAD-dependent deacetylase sirtuin-1 (hSIRT1) infosheet
UniprotKB AccessionQ96EB6
Alternative Name(s)SIR2-like protein 1 (hSIR2)
Eraser for PTM/s H4K16ac, H3K9ac, H1K25ac
EC number 3.5.1.-
No. of coding genesNAD-dependent deacetylase sirtuin-1 is coded by following 1 non-allelic gene/s
Gene namesirtuin 1
Gene symbolSIRT1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesSIR2L1
GeneID23411
Chromosomal location10q21
HGNC14929
UnigeneHs.369779
MIM604479
RefSeq mRNANM_001142498.1NM_012238.4
RefSeq ProteinNP_001135970.1NP_036370.2
Disease associations
Cancer: Colon carcinomas; PMID: 19433578
Cancer: Gastric cardiac carcinoma; PMID: 21865267
Cancer: Hepatocellular carcinoma (HCC); PMID: 21567102
Cancer: Breast carcinoma; PMID: 21056897
Cancer: Colon carcinomas; PMID: 19433578