Dual specificity protein phosphatase 1

In vitro report of H3S10 phosphatase activity (PMID: 19020052). It is reported to mediate both threonine as well as tyrosine dephosphorylation and is implicated in many depressive disorders (PMID: 20953200).

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Dual specificity protein phosphatase 1 infosheet
UniprotKB AccessionP28562
Alternative Name(s)Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1 (MAP kinase phosphatase 1, MKP-1), Protein-tyrosine phosphatase CL100
Eraser for PTM/s H3S10ph
EC number,
No. of coding genesDual specificity protein phosphatase 1 is coded by following 1 non-allelic gene/s
Gene namedual specificity phosphatase 1
Gene symbolDUSP1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sPTPN10
AliasesHVH1, CL100, MKP-1
Chromosomal location5q35.1
RefSeq mRNA
RefSeq Protein
Disease associations
Behavioural disorder: Depression; PMID: 20953200
Cancer: Non-small-cell Lung cancer (NSCLC); PMID: 20890299

Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit