Histone-lysine N-methyltransferase SETD1B

SETD1B is a SET domain containing methyltransferase that specifically methylates histone H3 at lysine 4 position. It functions in a non redundant manner with SETD1A (PMID: 17355966).

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Histone-lysine N-methyltransferase SETD1B infosheet
UniprotKB AccessionQ9UPS6
Alternative Name(s)Lysine N-methyltransferase 2G, SET domain-containing protein 1B (hSET1B)
Writer for PTM/s H3K4me3
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase SETD1B is coded by following 1 non-allelic gene/s
Gene nameSET domain containing 1B
Gene symbolSETD1B
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesKIAA1076, Set1B, KMT2G
GeneID23067
Chromosomal location12q24.31
HGNC29187
UnigeneHs.507122
MIM611055
RefSeq mRNANM_015048.1
RefSeq ProteinNP_055863.1
Disease associationsNo disease associations known for Histone-lysine N-methyltransferase SETD1B

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3