Histone-lysine N-methyltransferase SETMAR

SETMAR aroused from the fusion of a H3 methylase with a mariner family transposase and methylates histone H3 at lysine 36. It is reported to mediate Non Homologous End Joining (NHEJ) repair in case of DNA damage. It forms an open chromatin conformation and is thought to be responsible for integration of exogenous DNA (PMID: 16332963). SETMAR catalyses H3K36 dimethylation at the site of DNA double strand breaks which help in recruitment of early DNA repair components promoting enhanced DNA repair via NHEJ (PMID: 21187428). It is also shown to be involved in replication stress response whereby it promotes start of stalled replication forks (PMID: 20457750).

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Histone-lysine N-methyltransferase SETMAR infosheet
UniprotKB AccessionQ53H47
Alternative Name(s)SET domain and mariner transposase fusion gene-containing protein (HsMar1, Metnase)
Writer for PTM/s H3K36me2
EC number 2.1.1.43, 3.1.-.-
No. of coding genesHistone-lysine N-methyltransferase SETMAR is coded by following 1 non-allelic gene/s
Gene nameSET domain and mariner transposase fusion gene
Gene symbolSETMAR
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Aliasesmetnase
GeneID6419
Chromosomal location3p26.2
HGNC10762
UnigeneHs.475300
MIM609834
RefSeq mRNANM_006515.3
RefSeq ProteinNP_006506.3
Disease associationsNo disease associations known for Histone-lysine N-methyltransferase SETMAR

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3