Protein phosphatase 1D

WIP1 belongs to the PP2C family. It dephosphorylates gamma-H2AX (H2AS139ph; universal DNA damage marker), in vitro as well as in vivo. It is essential for suppressing DNA damage response after completion of DNA repair (PMID: 20118229).

Download table as Excel
Protein phosphatase 1D infosheet
UniprotKB AccessionO15297
Alternative Name(s)
Eraser for PTM/s H2AS139ph
EC number
No. of coding genesProtein phosphatase 1D is coded by following 1 non-allelic gene/s
Gene nameprotein phosphatase, Mg2+/Mn2+ dependent, 1D
Gene symbolPPM1D
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesWip1, PP2C-DELTA
Chromosomal location17q23.3
RefSeq mRNA
RefSeq Protein
Disease associations
Cancer: Breast cancer; PMID: 12021784
Cancer: Neuroblastoma; PMID: 12702577

Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit