H3R8ci
H3 arginine 8 citrullination by PADI4 helps in reversing the transcriptional activation brought about by the combined efforts of nuclear hormone receptor coactivators, histone arginine methyltransferases and histone deacetylases (PMID: 15345777). H3 deimination increases rapidly in response to neutrophile activation stimuli like LPS, TNF, lipoteichoic acid, f-MLP, or hydrogen peroxide and is released to the extracellular space as part of the neutrophil response to infections (PMID: 18209087). R8 deimination prevents methylation by CARM1 thus causing transcriptional repression of target genes (PMID: 15339660).
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| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Protein-arginine deiminase type-4 |
| Eraser/s | |
| Disease associations | Inflammatory disease: Multiple sclerosis (MS); PMID: 17079667 |
Sites of arginine citrullination H2AR3ci, H3R17ci, H3R26ci, H3R2ci, H3R8ci, H4R3ci