Bio322: Biophysics I Lecture Notes

[Ver. 2014]

1. Introduction
2. Energetics of life
3. Dimensional analysis & Orders of magnitude
4. Biology by numbers
   • Numbers and sizes
   • 18-Aug lect: [video]
   • Time and energy
5. Equilibrium in cells and bio-molecules
6. Protein folding and Levinthal's paradox
7. Entropy and Ligand-Receptor binding
8. Random walk polymers
9. Cytoskeleton and cellular biomechanics
   • Video of the lect on 3-Nov [bending of rods and cytoskeleton]
10. Membrane biophysics by Dr. Shiva Patil (please refer to the Phys Bio of the Cell book for notes)
11. Light in biology (interspersing aspects of the course)

Technique presentation slides and material [here]

1. [11-Sep Technique Presentation Videos]
2. [01-Nov Technique presentations videos (iiser-tvm)]
3. [10-Nov Technique presentations videos (iiser-tvm)]

Revision session [20-Nov-2014 video]

External sources & additional reading

Erwin Schrödinger (1944) "What is Life" [link]

Galileo Galilei's Dialogues Concerning Two New Sciences (U. Adelaide)

Powers of ten

Drosophila's circadian clock explained in a video "The Drosophila Molecular Clock Model"

Online physics simulations (incl. gene expression) PhET

Stochastic problems in physics and astronomy by S. Chandrashekhar (1943) Rev. of Modern Phys.

[Ver. 2013]

1. Introduction
2. Energetics of life
3. Dimensional analysis & orders of magnitude
4. Biology by numbers
5. Biological time scales
6. Equilibrium approach to cells and bio-molecules
7. Protein folding and Levinthal's paradox
8. Entropy and Ligand-Receptor binding
9. Random walk polymer
10. Cytoskeleton
11. Development
12. Membrane biophysics by Dr. Durba Sengupta
13. Light in biology by Dr. Mrinalini Puranik:
    • Introduction by Lackowicz,
    • Lecture notes and research paper by Kohler et al. (2007) Thymine dimerization in ultrafast photoreaction. Science [Click to open folder]

Technique presentation slides and material: access [here]

External lectures

Powers of ten

[Ver. 2012]

1. Introduction: why physical biology?
2. Energy in Biology
3. Biology by dimensionsal analysis and numbers
4. Equilibrium models: Free energy minimization of structures, Entropy and Levinthal's Paradox
5. Boltzmann distributions, ligand-receptor binding and two-state systems
6. Random walks and macromolecular structures and summary equations
7. Cell structure and cytoskeleton

Disclaimer: The lecture slides here are in support of the course Bio322 for the monsoon semester at IISER Pune. Material reproduced here from other sources is cited. Inadvertent oversight is regretted. The slides do NOT constitute claim of copyright in any way. This distribution is meant only for educational purposes. .