Bio322: Biophysics (Introduction to Physical Biology)
Physical biology of molecules, cells and tissues at equilibrium.
|Biology has progressed tremendously since the discovery of the
chemistry underlying it in terms of DNA, RNA, proteins and lipids. How
these interact with one another is however governed by physico-chemical
laws. This course will introduce these physical principles, key
experiments and models of the physical principles that govern the unit
of life- a cell and its components. It will also introduce means to
measure these aspects.
- TVM score distribution [plot]
- PUN score distribution [plot]
- Answer key
- IISER Pune students can see their answer papers from 10-Nov
onwards in the TA's lab (Neha Khetan, Main Block, 2nd floor,
Biology Wing, Bio-Computing Lab 01 (athale-lab)
- End-sem exam
[26-Nov-2014, time: 15-1700h (3-5pm)]. Due to
numerous emails about the portion: All semester material
with emphasis on the 2nd quarter (post-midsem), technique
presentation topics based on whatever is available (link to
original paper/report if any), presentations (if any) and video
talks (if any) together with those talks that were "live".
Principle of technique and link to rest of the course will be
- Bring calculators to the end-sem
exam. Paper will consist of multiple choice questions
- Revision session class video can be
accessed from the lectures
- Mid-sem exam answer
- In class hands-on session
(assignment): Persistence length
[optional and NOT MARKED]
- The Minisymposium on biophysics
technique for iiser-TVM students concludes with the last
session on 15-Nov (Sat, Time: 1600-1830h) (video
recorded)- PLEASE NOTE: We will begin at 4pm.
- 15-Nov @4pm: The new TA Ramesh
Bondada will coordinate with you to put ALL slides on one
computer before the start to reduce delays and technical
- iiserTvm: The video of the lecture on
3-Nov video can be accessed from the lecture-notes page.
- iiserPune: Technique presentations by
TVM students from 1st and 10th Nov are also linked to the lecture notes page.
- The assignment for RG has bee updated.
The problem with upload access has been fixed. Please upload ONE
PDF file here.
This should include the script you wrote to calculate
- The atom-movie: ibm-research used the
scanning tunneling microscope to make a movie out of CO atoms and
1.1. What, where, how, why biophysics?
1.2. Searching for information, citation, plagiarism and
- Order of magnitude physics, Energy and Life
2.1. Physical principles in biology; Energetics and order in
2,2. Dimensional analysis
2.3. Molecular scales and biology by numbers
- Cellular architecture
3.1 Nucleic acids 3.2 Construction plans for cells and organisms 3.4
Rate equations (differential equations) and dynamics of the cell 3.5
Biopolymers and cytoskeletal dynamics 3.6 Network organization in
space and time 3.7 Lipids, membranes and biophysics
- Biophysical techniques
- Light in biology, microscopy techniques
- Measuring forces in bio-molecules
- Movement of cells and analysis
- Measuring energetics of bio-molecular reactions.
- List of technique
presentation topics These are presentations you
students will make. This includes a signup form and a
list of summarized topics with dates.
plagiarism [pdf]: A document of what is acceptable usage of
existing (online, wikipedia, journal-article and other) sources.
Lecture slides and additional material from
|Assignments Late submission
policy: Scores will be scaled as
, (i.e. y= exp(-x/3)), where x=delay in days
after date of submission, and y=score.
Teaching assistant (TA)
Name: Neha Khetan (Pun), Kunalika Jain (Pun), Ramesh Bondada
Sreejith Alipra (Tvm)
Location: C301, HR4, E-classroom, 2nd floor, IISER Pune Campus
Meeting times for the instructor
Thurday 1100-1230h, Main Building, Biology Block, 2nd floor
Any other slot must be pre-arranged by appointment if you want to be sure to
For course and assignment related queries contact bio322 at the rate
students stop iiserpune stop ac dot indiain
- Nelson Philip: Biological Physics [free
pdf] by Philip Nelson.
- Philips, Kondev, Theriot: Physical Biology of the Cell [link]
- Berg Howard: Random Walks in Biology [link]
- Sanjoy Mahajan:Order of Magnitude Physics [pdf]-
a full course at Caltech
- Thomas M. Nordlund (2011) Quantitative Understanding of
Biosystems: An Introduction to Biophysics CRC Press.
- Mid-semester exams: 22 to 27-Sep
- End-semester exams: 24 to 29-Nov
Last update: 9-Dec-2014