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A few images from our published work are presented here. For more details, please visit publications page.
About Us
Life would have been much easier if the human eye could visualize, with high enough resolution and fast enough speed, biomolecules performing their tasks – for example, a live view of an RNA base being extruded out of the helical stack upon binding of a drug molecule would directly tell us the binding mode and other biophysical details needed to design the drug effectively and efficiently. Until we attain those powers, we have to rely on spectroscopy to visualize such motions in biomolecules indirectly.
We use (and develop) solution-state high-resolution NMR experiments combined with other biophysical techniques and computational approaches to study the conformational dynamics of proteins and nucleic acids (DNA and RNA) at atomic resolution. We believe these dynamic ensembles (and not just static structures) provide better visualization of the detailed biomolecular behavior upon getting a cellular signal.
In addition, we also use NMR spectroscopy to look at the metabolic profiles of various cells, tissues, body fluids, etc., to understand the stress response in an organism.
We are housed in Main Building at the Indian Institute of Science Education and Research (IISER), Pune, Maharashtra, India.
Recent Lab News
Let Us Resonate Together – Open Positions
We are always looking for highly motivated candidates for
- Summer/Winter projects (2 months),
- Semester projects (4 months),
- MS projects (6-12 months, depending upon the degree awarding institute),
- Ph.D. (5-6 years),
- and Post-Doc (1-2 years).
Write to me about what you want to work on in a one-page write-up if you are interested in working with our group. Students from Physical Chemistry/Biology/Physics are welcome to apply.
Current Lab Funding
Institute grant by IISER Pune |  |
DST-SERB (approved 2023) |  |
DHR-ICMR (Dec 2023-Nov 2026) |  |
Past Lab Funding
DBT (BT/PR24185/BRB/10/1605/2017) (April 2018 to March 2021) |  |
International Collaborative Research Grant, Osaka University, Japan (April 2019 to March 2020) |  |
DST-SERB (EMR/2015/001966) (April 2016 to March 2019) | |
International Collaborative Research Grant, Osaka University, Japan (April 2018 to March 2019) | |
Start-up grant by IISER Pune | |