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About the infobase
HIstome is a combined effort of researchers from two institutions, Advanced Center for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai and Center of Excellence in Epigenetics (CoEE), Indian Institute of Science Education and Research (IISER), Pune.
Introduction
HIstome is a freely available, specialist, electronic database dedicated to display infomation about human histone variants, sites of their post-translational modifications and about various histone modifying enzymes. HIstome data is available by browsing the contents.
The database covers 5 types of histones, 8 types of their post-translational modifications and 13 classes of modifying enzymes. Current version contains information for about ~50 histone proteins and ~150 histone modifying enzymes. Many data fields are hyperlinked to other databases (e.g. UnprotKB/Swiss-Prot, HGNC, OMIM, Unigene etc.). Additionally, this database also provides sequences of promoter regions (-700 TSS +300) for all gene entries. These sequences were extracted from the UCSC genome browser. Sites of post-translational modifications of histones were manually searched from PubMed listed literature.
This infobase would be of use to biology researchers, especially those interested in epigenetic regulation. We welcome suggestions from the scientific community.
How to cite
Khare SP*1,2, Habib F*2, Sharma R2, Gadewal N1, Gupta S†1, Galande S†2; HIstome: a relational knowledgebase of human histone proteins and histone modifying enzymes (Nucleic Acids Research (2011) Database issue doi:10.1093/nar/gkr1125). PubMed ID: 22140112
1Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai 410210
2Centre for Excellence in Epigenetics, Indian Institute of Science Education and Research (IISER), Pune 411021, India
* - Equal Contribution
† - Authors for correspondence