Histone Arginine demethylases
Only one enzyme is known to show histone arginine demethylation activity in humans. It belongs to 2-oxoglutarate (2-OG)-dependent oxygenases. The mechanism involves hydroxylation of methyl group followed by deformylation.
Further reading: PMID: 16513174.
Cytogenetic map of Arginine demethylases coding genes| Enzyme (UniprotKB recommended name) | Coding gene/s | Site of histone modification |
|---|---|---|
| Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | JMJD6 | H3R2me2, H4R3me1, H4R3me2 |