Histone Arginine demethylases

Only one enzyme is known to show histone arginine demethylation activity in humans. It belongs to 2-oxoglutarate (2-OG)-dependent oxygenases. The mechanism involves hydroxylation of methyl group followed by deformylation.

Further reading: PMID: 16513174.

Cytogenetic map of Arginine demethylases coding genes
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Different histone Arginine demethylases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6JMJD6H3R2me2, H4R3me1, H4R3me2