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PRMT5 are required for dimethylation of H4R3 at gama-globin gene locus in erythroid cells. This mark serves as a binding site for DNMT3A (PMID: 19234465). It facilitates subsequent acetylation of H3 and H4, resulting in gene activation (PMID: 16103216).

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H4R3me2 infosheet
Modified variants Histone H4
Writer/s Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6
Eraser/s Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Disease associations
Blood disorder: Beta-thalassemia, sickle cell disease (SCD); PMID: 19234465

Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2