Histone Lysine ribosylases

Poly (ADP-ribose) Polymerase (PARP) is a class of enzyme that catalyse the poly ADP-ribosylation of various nuclear proteins. Histones are one of the targets of these enzymes and PARP1 catalyses the transfer of ADP-ribose group from Nicotinamide adenine dinucleotide (NAD) (donor) to the lysine residue of histones or to an already exhisting poly(ADP-ribose) chain.

Poly ADP-ribosylation of histones leads to change in the chromatin structure and has been shown to affect transcription regulation.

Cytogenetic map of Lysine ribosylases coding genes
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Different histone Lysine ribosylases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Poly [ADP-ribose] polymerase 1PARP1H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar