Histone Lysine biotinases

There is only a single biotinase known in humans. Its activity is cell cycle dependent. It binds to biotin and catalyses the reaction in 2 steps. First step: activation of biotin by addition of AMP to give biotinyl-5'-AMP. This step utilizes ATP as a donor. Second step: transfer to histones via removal of AMP. Deficiency of this enzymes leads to an autosomal recessive disorder called multiple carboxylase deficiency (MCD).

Further reading: PMID: 15992689.

Cytogenetic map of Lysine biotinases coding genes
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Different histone Lysine biotinases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Biotin--protein ligaseHLCSH3K9bio, H3K18bio, H4K12bio, H4K8bio