Biotin--protein ligase
HCS belongs to the biotin-protein ligase family. It catalyses the addition of biotin groups on histone H3 at lysine 9 and 18 position (PMID: 20688500). HCS is predominantly present inside the nucleus and is shown to be attached to the nuclear matrix (PMID: 14613969). Biotinylation of histones increases during cell cycle and is observed to be highest in proliferating cells (PMID: 11606205). H4K12 biotinylation is significant since it is reported to silence Long Terminal Repeats (LTR)(PMID: 19812216). miR-539 is shown to play a critical role in regulation of HCS (PMID: 20592104).
| UniprotKB Accession | P50747 |
|---|---|
| Alternative Name(s) | Biotin apo-protein ligase |
| Writer for PTM/s | H3K9bio, H3K18bio, H4K12bio, H4K8bio |
| EC number | 6.3.4.-, 6.3.4.9, 6.3.4.10, 6.3.4.11, 6.3.4.15 |
| No. of coding genes | Biotin--protein ligase is coded by following 1 non-allelic gene/s |
| Gene name | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) |
| Gene symbol | HLCS |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | HCS |
| GeneID | 3141 |
| Chromosomal location | 21q22.1 |
| HGNC | 4976 |
| Unigene | Hs.371350 |
| MIM | 609018 |
| RefSeq mRNA | NM_000411.5 |
| RefSeq Protein | NP_000402.3 |
| Disease associations | No disease associations known for Biotin--protein ligase |
Lysine biotinases Biotin--protein ligase