Histone Arginine deiminases
Enzymes in this category include protein arginine deiminases (PADs). Protein arginine deiminases catalyse the hydrolysis of guanidinium side chains of arginine residues to form citrulline and ammonia. Five types of PADs are found in humans; namely PAD1, PAD2, PAD3, PAD4 and PAD6. Out of these PAD4 has been implicated in histone arginine deimination.
Further reading: (PMID: 18603028, PMID: 14579251, PMID: 17342184).
Cytogenetic map of Arginine deiminases coding genes| Enzyme (UniprotKB recommended name) | Coding gene/s | Site of histone modification |
|---|---|---|
| Protein-arginine deiminase type-4 | PADI4 | H3R2ci, H3R8ci, H3R17ci, H3R26ci, H2AR3ci, H4R3ci |