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H3R2ci

PADI4 catalyses deimination at R2 position on H3. This activity inhibits the methylation of these residues by CARM1 thus causing transcriptional repression of target genes (PMID: 15339660).


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H3R2ci infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Protein-arginine deiminase type-4
Eraser/s
Disease associations
Inflammatory disease: Multiple sclerosis (MS); PMID: 17079667

Sites of arginine citrullination H2AR3ci, H3R17ci, H3R26ci, H3R2ci, H3R8ci, H4R3ci