Histone H3.1

Histone H3.1 variant expression is replication dependent (PMID: 16571659). It encompasses modifications that mark transcriptional activation as well as repression (PMID: 16267050). Some reports also demonstrate incorporation of H3.1 outside of S phase and at the site of UV induced DNA damage by specific mechanisms, suggesting a role in DNA damage response and formation of a damage memory (PMID: 17081972). Studies performed on nucleosomal assembly suggest that H3.1/H4 tetramers do not split and remain intact during replication dependent deposition of H3.1 variant (PMID: 20360108).

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Histone H3.1 infosheet
UniprotKB AccessionP68431
Alternative Name(s)
No. of coding genesHistone H3.1 is coded by following 10 non-allelic gene/s
Gene namehistone cluster 1, H3ahistone cluster 1, H3dhistone cluster 1, H3chistone cluster 1, H3ehistone cluster 1, H3ihistone cluster 1, H3ghistone cluster 1, H3jhistone cluster 1, H3hhistone cluster 1, H3bhistone cluster 1, H3f
Promoter region (-700 TSS +300)Get sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequence
AliasesH3/AH3/bH3/c, H3.1H3/d, H3.1H3/f, H3.fH3/hH3/jH3/k, H3F1KH3/lH3/i
Chromosomal location6p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.1
RefSeq mRNANM_003529.2NM_003530.3NM_003531.2NM_003532.2NM_003533.2NM_003534.2NM_003535.2NM_003536.2NM_003537.3NM_021018.2
RefSeq ProteinNP_003520.1NP_003521.2NP_003522.1NP_003523.1NP_003524.1NP_003525.1NP_003526.1NP_003527.1NP_003528.1NP_066298.1
Disease associationsNo disease associations known for Histone H3.1

Histone H3 variants Histone H3-like centromeric protein A, Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3, Histone H3.3C