Histone H3.1

Histone H3.1 variant expression is replication dependent (PMID: 16571659). It encompasses modifications that mark transcriptional activation as well as repression (PMID: 16267050). Some reports also demonstrate incorporation of H3.1 outside of S phase and at the site of UV induced DNA damage by specific mechanisms, suggesting a role in DNA damage response and formation of a damage memory (PMID: 17081972). Studies performed on nucleosomal assembly suggest that H3.1/H4 tetramers do not split and remain intact during replication dependent deposition of H3.1 variant (PMID: 20360108).

Click on PTM for further information Notice: Use of undefined constant extract_pos - assumed 'extract_pos' in /var/home/coee/public_html/histome/variants.php on line 60 Notice: Use of undefined constant extract_pos_mod - assumed 'extract_pos_mod' in /var/home/coee/public_html/histome/variants.php on line 61

Download table as Excel
Histone H3.1 infosheet
UniprotKB AccessionP68431
Alternative Name(s)
No. of coding genesHistone H3.1 is coded by following 10 non-allelic gene/s
Gene namehistone cluster 1, H3ahistone cluster 1, H3dhistone cluster 1, H3chistone cluster 1, H3ehistone cluster 1, H3ihistone cluster 1, H3ghistone cluster 1, H3jhistone cluster 1, H3hhistone cluster 1, H3bhistone cluster 1, H3f
Gene symbolHIST1H3AHIST1H3DHIST1H3CHIST1H3EHIST1H3IHIST1H3GHIST1H3JHIST1H3HHIST1H3BHIST1H3F
Promoter region (-700 TSS +300)Get sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequence
Previous Symbol/sH3FAH3FBH3FCH3FDH3FFH3FHH3FJH3FKH3FLH3FI
AliasesH3/AH3/bH3/c, H3.1H3/d, H3.1H3/f, H3.fH3/hH3/jH3/k, H3F1KH3/lH3/i
GeneID8350835183528353835483558356835783588968
Chromosomal location6p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.1
HGNC4766476747684769477147724774477547764773
UnigeneHs.546315Hs.532144Hs.248176Hs.443021Hs.132854Hs.247813Hs.484990Hs.591778Hs.533292Hs.247814
MIM602810602811602812602813602814602815602817602818602819602816
RefSeq mRNANM_003529.2NM_003530.3NM_003531.2NM_003532.2NM_003533.2NM_003534.2NM_003535.2NM_003536.2NM_003537.3NM_021018.2
RefSeq ProteinNP_003520.1NP_003521.2NP_003522.1NP_003523.1NP_003524.1NP_003525.1NP_003526.1NP_003527.1NP_003528.1NP_066298.1
Disease associationsNo disease associations known for Histone H3.1

Histone H3 variants Histone H3-like centromeric protein A, Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3, Histone H3.3C