Histone H3.3

Histone H3.3 is expressed in a replication independent manner (PMID: 16571659). H3.3 specific serine 31 phosphorylation is observed in the adjoining regions of the centromere during the metaphase stage and supposed to contribute to cell cycle (PMID: 15851689). Majority of modifications present on H3.3 represent a transcriptionally active region of the chromatin (PMID: 16267050). Histone chaperones Asf1A and Asf1B are required for deposition of histone H3.3 (PMID: 18378699). Studies performed on nucleosome assembly suggest that H3.3/H4 tetramers show maximum splitting during replication dependent deposition of H3.3 variant (PMID: 20360108). Recently a study reports, death domain-associated protein DAXX, as an H3.3 variant specific chaperone in humans that deposits H3.3 in a replication independent manner (PMID: 20504901).

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Histone H3.3 infosheet
UniprotKB AccessionP84243
Alternative Name(s)
No. of coding genesHistone H3.3 is coded by following 2 non-allelic gene/s
Gene nameH3 histone, family 3AH3 histone, family 3B (H3.3B)
Gene symbolH3F3AH3F3B
Promoter region (-700 TSS +300)Get sequenceGet sequence
Previous Symbol/sH3F3
Chromosomal location1q42.1217q25.1
RefSeq mRNANM_002107.4NM_005324.3
RefSeq ProteinNP_002098.1NP_005315.1
Disease associations
CancerBreast cancer12151336

Histone H3 variants Histone H3-like centromeric protein A, Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3, Histone H3.3C