Histone H3.1t
Tissue specific histone H3 variant is expressed exclusively in testis and restricted to primary spermatocytes (PMID: 8986613). Nap2 is reported to facilitate efficient nucleosome assembly with H3.1t/H4 in in vitro conditions (PMID: 18281699). Nucleosomes containing H3.1t in place of conventional H3 are found to be structurally very unstable in both, in vivo and in vitro conditions. This property is thought to be important for the dense packaging of chromatin inside sperms (PMID: 20498094).
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| UniprotKB Accession | Q16695 |
|---|---|
| Alternative Name(s) | H3/g |
| No. of coding genes | Histone H3.1t is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 3, H3 |
| Gene symbol | HIST3H3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H3FT |
| Aliases | H3t, H3/g |
| GeneID | 8290 |
| Chromosomal location | 1q42.13 |
| HGNC | 4778 |
| Unigene | Hs.248171 |
| MIM | 602820 |
| RefSeq mRNA | NM_003493.2 |
| RefSeq Protein | NP_003484.1 |
| Disease associations | No disease associations known for Histone H3.1t |
Histone H3 variants Histone H3-like centromeric protein A, Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3, Histone H3.3C