Histone H3-like centromeric protein A

CENPA is a centromere specific histone H3 variant and localizes to the centromeric hetrochromatinised regions of the genome (PMID: 7962047, PMID: 10639145). CENPA is essential for the formation of kinetochores and recruitment of other factors required for spindle assembly (PMID: 11682612). Histone modifications present in the centromeric region are significantly different from the euchromatic or hetrochromatic regions and is supposed to be partly enabled by CENP-A (PMID: 15475964). CENPA is also shown to be recruited at the sites of DNA damage and this event is independent of H2A.X signal (PMID: 19717431). CENPA is incorporated specifically at centromeric region by the coordination of different molecules like nucleophosmin 1, and HJURP (PMID: 19410544).

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Histone H3-like centromeric protein A infosheet
UniprotKB AccessionP49450
Alternative Name(s)Centromere autoantigen A, Centromere protein A (CENP-A)
No. of coding genesHistone H3-like centromeric protein A is coded by following 1 non-allelic gene/s
Gene namecentromere protein A
Gene symbolCENPA
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location2p24-p21
RefSeq mRNANM_001042426.1NM_001809.3
RefSeq ProteinNP_001035891.1NP_001800.1
Disease associations
CancerHepatocellular carcinoma17535684
CancerHumancolorectal cancer12839935
CancerHuman testicular germ cell tumors17970049

Histone H3 variants Histone H3-like centromeric protein A, Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3, Histone H3.3C