H4K12bio
H4K12 is a preferred site for biotinylation (PMID: 15153116). Biotinylated histone H4 is enriched in pericentromeric heterochromatin, and that biotinylation of histone H4 participates in gene silencing, mitotic condensation of chromatin, and the cellular response to DNA damage(PMID: 16772434).
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| Modified variants | Histone H4 |
|---|---|
| Writer/s | Biotin--protein ligase |
| Eraser/s | |
| Disease associations | No disease associations known for H4K12bio |
Sites of lysine biotinylation H2AK125bio, H2AK127bio, H2AK129bio, H2AK13bio, H2AK9bio, H3K18bio, H3K9bio, H4K12bio, H4K8bio