H4K16ar
Different acetylation patterns on histone H4 are subjected to binding of different number of ADP-ribosyl units. Poly ADP ribosylation of histone H4 plays an important role during chromatin replication (PMID: 2387872). Important in shuttling of histones in and out of DNA (PMID: 1326536). It s also implicated in DNA excision repair (PMID: 1429884).
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| Modified variants | Histone H4 |
|---|---|
| Writer/s | Poly [ADP-ribose] polymerase 1 |
| Eraser/s | |
| Disease associations | No disease associations known for H4K16ar |
Sites of lysine ribosylation H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar