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Different acetylation patterns on histone H4 are subjected to binding of different number of ADP-ribosyl units. Poly ADP ribosylation of histone H4 plays an important role during chromatin replication (PMID: 2387872). Important in shuttling of histones in and out of DNA (PMID: 1326536). It s also implicated in DNA excision repair (PMID: 1429884).

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H4K16ar infosheet
Modified variants Histone H4
Writer/s Poly [ADP-ribose] polymerase 1
Disease associationsNo disease associations known for H4K16ar

Sites of lysine ribosylation H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar