Protein arginine N-methyltransferase 5
JBP1 is a methyltransferase with specificity towards histone H2A and H4 (PMID: 10531356). PRMT5 is shown to catalyse monomethylation and symmetric dimethylation of arginine residues (PMID: 11413150). PRMT5 is shown to promote cancer by stimulating anchorage-independent growth and inhibiting tumour suppressor genes (PMID: 15485929) (PMID: 18694959). It is also involved in gene silencing via methylation of H4R3 and recruitment of DNMT3A (PMID: 19234465). PRMT5 is reported to show increased activity in many human cancers (PMID: 20951943). PRMT5 translation is differentially regulated by mir-92b/96 in normal and malignant human lymphocytes (PMID: 17627275).
| UniprotKB Accession | O14744 | |
|---|---|---|
| Alternative Name(s) | 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog (SKB1 homolog, SKB1Hs) | |
| Writer for PTM/s | H3R8me2, H4R3me2 | |
| EC number | 2.1.1.-, 2.1.1.125 | |
| No. of coding genes | Protein arginine N-methyltransferase 5 is coded by following 1 non-allelic gene/s | |
| Gene name | protein arginine methyltransferase 5 | |
| Gene symbol | PRMT5 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | HRMT1L5, SKB1 | |
| Aliases | SKB1Hs | |
| GeneID | 10419 | |
| Chromosomal location | 14q11.2 | |
| HGNC | 10894 | |
| Unigene | Hs.367854 | |
| MIM | 604045 | |
| RefSeq mRNA | NM_001039619.1 | NM_006109.3 |
| RefSeq Protein | NP_001034708.1 | NP_006100.2 |
| Disease associations | Cancer: Testicular tumors; PMID: 17437848 | |
Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8