Protein arginine N-methyltransferase 8
PRMT8 is shown to catalyse the in vitro methylation of histone H4. It is also shown to mediate monomethylation and asymmetric dimethylation. PRMT8 is tissue specific and expressed in brain. It differs from other PRMTs as it is often found associated with the plasma membrane (PMID: 16051612). Reports suggest that the N-terminal tail of PRMT8 has autoregulatory activity (PMID: 17925405).
| UniprotKB Accession | Q9NR22 |
|---|---|
| Alternative Name(s) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 |
| Writer for PTM/s | |
| EC number | 2.1.1.- |
| No. of coding genes | Protein arginine N-methyltransferase 8 is coded by following 1 non-allelic gene/s |
| Gene name | protein arginine methyltransferase 8 |
| Gene symbol | PRMT8 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | HRMT1L3, HRMT1L4 |
| Aliases | |
| GeneID | 56341 |
| Chromosomal location | 12p13.3 |
| HGNC | 5188 |
| Unigene | Hs.504530 |
| MIM | 610086 |
| RefSeq mRNA | NM_019854.3 |
| RefSeq Protein | NP_062828.3 |
| Disease associations | No disease associations known for Protein arginine N-methyltransferase 8 |
Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8