Histone-arginine methyltransferase CARM1

CARM1 belongs to the PRMT family of methyltransferases and catalyses monomethylation and asymmetric dimethylation of histone H3 at arginine 17 position and monomethylates arginine at position 2 and 26, which is reported to be linked to nuclear hormone receptor regulated transcriptional activation (PMID: 11751582, PMID: 16497732, PMID: 15186775). CARM1 methylates CREB-binding protein (CBP) in order to promote co-activation of transcription (PMID: 12374746). It is a part of nucleosomal methylation activator complex (NUMAC) which plays an important role in the regulation of nuclear-receptor signalling pathway (PMID: 14729568). CARM1 mediated methylation of H3R17 is involved in the activation of NF-kB target genes and also in the regulation of inflammatory genes in monocytes (PMID: 16497732). It also regulates E2F1, a transcription factor implicated in oestrogen dependent breast cancers (PMID: 18172323).

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Histone-arginine methyltransferase CARM1 infosheet
UniprotKB AccessionQ86X55
Alternative Name(s)Coactivator-associated arginine methyltransferase 1, Protein arginine N-methyltransferase 4
Writer for PTM/s H3R17me1, H3R17me2, H3R2me1, H3R26me1
EC number 2.1.1.-,
No. of coding genesHistone-arginine methyltransferase CARM1 is coded by following 1 non-allelic gene/s
Gene namecoactivator-associated arginine methyltransferase 1
Gene symbolCARM1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location19p13.2
RefSeq mRNANM_199141.1
RefSeq ProteinNP_954592.1
Disease associations
Cancer: Prostate cancer; PMID: 16705743
Cancer: Colorectal cancer; PMID: 20462455

Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8