Protein arginine N-methyltransferase 1
PRMT1 belongs to the PRMT family of methyltransferases and catalyse the monomethylation and asymmetric dimethylaion of H4 at arginine 3 position which is responsible for transcriptional activation (PMID: 11387442, PMID: 17891136). PRMT1 mediated H4R3 methylation in the regulatory regions facilitates a primed state of myeloid differentiation upon retinoid induction. This leads to creation of an epigenetic transcriptional memory (PMID: 15964820). It is also reported to regulate nuclear hormone induced transcriptional activation by a dual mode (PMID: 17052457). PRMT1 is a part of an oncogenic transcriptional complex and is thought to be a potential target for therapy (PMID: 17891136). PRMT1 in association with CARM1 is reported to regulate the NF-kB target gene expression (PMID: 18280497).
| UniprotKB Accession | Q99873 | |
|---|---|---|
| Alternative Name(s) | Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4 | |
| Writer for PTM/s | H4R3me1, H4R3me2 | |
| EC number | 2.1.1.-, 2.1.1.125 | |
| No. of coding genes | Protein arginine N-methyltransferase 1 is coded by following 1 non-allelic gene/s | |
| Gene name | protein arginine methyltransferase 1 | |
| Gene symbol | PRMT1 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | HRMT1L2 | |
| Aliases | HCP1, ANM1 | |
| GeneID | 3276 | |
| Chromosomal location | 19q13 | |
| HGNC | 5187 | |
| Unigene | Hs.20521 | |
| MIM | 602950 | |
| RefSeq mRNA | NM_001536.3 | NM_198318.2 |
| RefSeq Protein | NP_001527.3 | NP_938074.2 |
| Disease associations | Cancer: Colon cancer; PMID: 19078953 | |
Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8