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H4 R3 methylation plays a major role in transcriptional activation by nuclear hormone receptors. Methylation of arginine 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300 (PMID: 11387442). H4R3 methylation stimulates subsequent acetylation of H3 and H4 resulting in gene activation (PMID: 16103216).

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H4R3me1 infosheet
Modified variants Histone H4
Writer/s Protein arginine N-methyltransferase 1
Eraser/s Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Disease associationsNo disease associations known for H4R3me1

Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2