H3R2me2
H3R2 methyl marks are selectively and locally depleted from active promoters. PRMT6-mediated methylation of R2 in histone H3 antagonises H3 K4 trimethylation (PMID: 18079182). Likewise, H3R2 methylation by PRMT6 was prevented by the presence of H3K4me3 on the H3 tail (PMID: 17898714).
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| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Protein arginine N-methyltransferase 6 |
| Eraser/s | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 |
| Disease associations | No disease associations known for H3R2me2 |
Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2