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H3R2 methyl marks are selectively and locally depleted from active promoters. PRMT6-mediated methylation of R2 in histone H3 antagonises H3 K4 trimethylation (PMID: 18079182). Likewise, H3R2 methylation by PRMT6 was prevented by the presence of H3K4me3 on the H3 tail (PMID: 17898714).

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H3R2me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Protein arginine N-methyltransferase 6
Eraser/s Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Disease associationsNo disease associations known for H3R2me2

Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2