Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
JMJD6 is an iron- and 2-oxoglutarate-dependent dioxygenase. It is the only known histone arginine demethylase in humans. It catalyses the demethylation of H3R2me2, H4R3me2 and H4R3me1 (PMID: 17947579). It is shown to regulate RNA splicing in a specific manner by virtue of its hydroxylase activity (PMID: 19574390). JMJD6 binds most efficiently with single stranded RNA (PMID: 20679243).
| UniprotKB Accession | Q6NYC1 | |
|---|---|---|
| Alternative Name(s) | Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, Jumonji domain-containing protein 6, Lysyl-hydroxylase JMJD6, Peptide-lysine 5-dioxygenase JMJD6, Phosphatidylserine receptor (Protein PTDSR) | |
| Eraser for PTM/s | H3R2me2, H4R3me1, H4R3me2 | |
| EC number | 1.14.11.- | |
| No. of coding genes | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is coded by following 1 non-allelic gene/s | |
| Gene name | jumonji domain containing 6 | |
| Gene symbol | JMJD6 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | PTDSR | |
| Aliases | PTDSR1, KIAA0585 | |
| GeneID | 23210 | |
| Chromosomal location | 17q25 | |
| HGNC | 19355 | |
| Unigene | Hs.514505 | |
| MIM | 604914 | |
| RefSeq mRNA | NM_001081461.1 | NM_015167.2 |
| RefSeq Protein | NP_001074930.1 | NP_055982.2 |
| Disease associations | No disease associations known for Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | |
Arginine demethylases Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6