Protein arginine N-methyltransferase 6
PRMT6 belongs to the PRMT family of methyltransferases and is found exclusively inside the nucleus (PMID: 11724789). PRMT6 is shown to methylate an HIV protein Tat and negatively regulates HIV replication (PMID: 15596808). PRMT6 catalysed methylation of DNA polymerase beta is shown to enhance its DNA binding property and hence regulates base excision repair (BER) (PMID: 16600869). H3R2 dimethylation antagonises the H3K4 methyl activation marks and hence represses transcription (PMID: 18079182). PRMT6 is implicated in human carcinogenesis (PMID: 20473859).
| UniprotKB Accession | Q96LA8 |
|---|---|
| Alternative Name(s) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6 |
| Writer for PTM/s | H3R2me2, H4R3me2, H2AR3me2 |
| EC number | 2.1.1.-, 2.1.1.125 |
| No. of coding genes | Protein arginine N-methyltransferase 6 is coded by following 1 non-allelic gene/s |
| Gene name | protein arginine methyltransferase 6 |
| Gene symbol | PRMT6 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | HRMT1L6 |
| Aliases | FLJ10559 |
| GeneID | 55170 |
| Chromosomal location | 1p13.2 |
| HGNC | 18241 |
| Unigene | Hs.26006 |
| MIM | 608274 |
| RefSeq mRNA | NM_018137.2 |
| RefSeq Protein | NP_060607.2 |
| Disease associations | Cancer: Leukemia; PMID: 18694959 |
Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8