H3R17me2
CARM1 dependent methylation of H3R17 leads to the activation of E2F1 promoter indicating its role in gene activation (PMID: 18172323). H3R17me2 is important for transcriptional activation of MHC II HLA-DRA genes (PMID: 17478518).
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Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
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Writer/s | Histone-arginine methyltransferase CARM1 |
Eraser/s | |
Disease associations | Cancer: Breast cancer; PMID: 18172323 Cancer: Prostate cancer; PMID: 16705743 |
Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2