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CARM1 dependent methylation of H3R17 leads to the activation of E2F1 promoter indicating its role in gene activation (PMID: 18172323). H3R17me2 is important for transcriptional activation of MHC II HLA-DRA genes (PMID: 17478518).

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H3R17me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-arginine methyltransferase CARM1
Disease associations
Cancer: Breast cancer; PMID: 18172323
Cancer: Prostate cancer; PMID: 16705743

Sites of arginine methylation H2AR3me2, H3R17me1, H3R17me2, H3R26me1, H3R2me1, H3R2me2, H3R8me2, H4R3me1, H4R3me2