Poly(ADP-ribose) glycohydrolase
PARG catalyses the degradation of poly ADP-ribose chains on all core histones. The immediate effect is that the histones are free to reconstitute back with the DNA to form chromatin in in vitro conditions. PARG works in synchrony with PARPs to coordinate regulation during DNA excision repair events (PMID: 1326536, PMID: 17548475).
| UniprotKB Accession | Q86W56 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | |
| EC number | |
| No. of coding genes | Poly(ADP-ribose) glycohydrolase is coded by following 1 non-allelic gene/s |
| Gene name | poly (ADP-ribose) glycohydrolase |
| Gene symbol | PARG |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | |
| GeneID | 8505 |
| Chromosomal location | 10q11.23 |
| HGNC | 8605 |
| Unigene | Hs.535298 |
| MIM | 603501 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | No disease associations known for Poly(ADP-ribose) glycohydrolase |
Lysine deribosylase Poly(ADP-ribose) glycohydrolase