Poly(ADP-ribose) glycohydrolase

PARG catalyses the degradation of poly ADP-ribose chains on all core histones. The immediate effect is that the histones are free to reconstitute back with the DNA to form chromatin in in vitro conditions. PARG works in synchrony with PARPs to coordinate regulation during DNA excision repair events (PMID: 1326536, PMID: 17548475).

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Poly(ADP-ribose) glycohydrolase infosheet
UniprotKB AccessionQ86W56
Alternative Name(s)
Eraser for PTM/s
EC number
No. of coding genesPoly(ADP-ribose) glycohydrolase is coded by following 1 non-allelic gene/s
Gene namepoly (ADP-ribose) glycohydrolase
Gene symbolPARG
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location10q11.23
RefSeq mRNA
RefSeq Protein
Disease associationsNo disease associations known for Poly(ADP-ribose) glycohydrolase

Lysine deribosylase Poly(ADP-ribose) glycohydrolase