Poly [ADP-ribose] polymerase 1
PARP1 mediates the poly ADP-ribosylation of histone H1 in context of DNA damage repair (PMID: 6693402). It is also implicated in many neuronal disorders in humans (PMID: 17084037). PARP1 is known to interact with macro domain of macro-H2A that leads to inhibition of PARP1 activity and silencing of inactive X chromosome (PMID: 17158748, PMID: 17322296). H4K16 acetylation marks inhibit the subsequent poly ADP-ribosylation by PARP1(PMID: 20525793). PARP1 also controls and contributes to the process of DNA damage repair by interacting with chromatin remodellers (PMID: 19661379). Recent reports demonstrate that PARP1 in association with BRG1 and HDAC significantly influences the process of cardiac development (PMID: 20596014).
| UniprotKB Accession | P09874 |
|---|---|
| Alternative Name(s) | NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), Poly[ADP-ribose] synthase 1 |
| Writer for PTM/s | H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar |
| EC number | 2.4.2.30 |
| No. of coding genes | Poly [ADP-ribose] polymerase 1 is coded by following 1 non-allelic gene/s |
| Gene name | poly (ADP-ribose) polymerase 1 |
| Gene symbol | PARP1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | PPOL, ADPRT |
| Aliases | PARP |
| GeneID | 142 |
| Chromosomal location | 1q41-q42 |
| HGNC | 270 |
| Unigene | Hs.177766 |
| MIM | 173870 |
| RefSeq mRNA | NM_001618.3 |
| RefSeq Protein | NP_001609.2 |
| Disease associations | No disease associations known for Poly [ADP-ribose] polymerase 1 |
Lysine ribosylases Poly [ADP-ribose] polymerase 1