Poly [ADP-ribose] polymerase 1

PARP1 mediates the poly ADP-ribosylation of histone H1 in context of DNA damage repair (PMID: 6693402). It is also implicated in many neuronal disorders in humans (PMID: 17084037). PARP1 is known to interact with macro domain of macro-H2A that leads to inhibition of PARP1 activity and silencing of inactive X chromosome (PMID: 17158748, PMID: 17322296). H4K16 acetylation marks inhibit the subsequent poly ADP-ribosylation by PARP1(PMID: 20525793). PARP1 also controls and contributes to the process of DNA damage repair by interacting with chromatin remodellers (PMID: 19661379). Recent reports demonstrate that PARP1 in association with BRG1 and HDAC significantly influences the process of cardiac development (PMID: 20596014).

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Poly [ADP-ribose] polymerase 1 (PARP-1) infosheet
UniprotKB AccessionP09874
Alternative Name(s)NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), Poly[ADP-ribose] synthase 1
Writer for PTM/s H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar
EC number
No. of coding genesPoly [ADP-ribose] polymerase 1 is coded by following 1 non-allelic gene/s
Gene namepoly (ADP-ribose) polymerase 1
Gene symbolPARP1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sPPOL, ADPRT
Chromosomal location1q41-q42
RefSeq mRNANM_001618.3
RefSeq ProteinNP_001609.2
Disease associationsNo disease associations known for Poly [ADP-ribose] polymerase 1

Lysine ribosylases Poly [ADP-ribose] polymerase 1