Histone Arginine citrullination

Citrullination (ci) is also referred to as Deimination. This modification occurs at specific arginine residues in histone peptides and is mediated by Protein arginine deiminase enzymes (PAD). Catalysis involves conversion of [-C(NH)- to -C(O)-] in the arginine residue side chain. Citrullination has an important role during events like cellular apoptosis. This modification prevents the subsequent methylation of arginine residues by other methyltransferase like CARM1.


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Sites of histone Arginine citrullination
Site of modification Writers Erasers
H2AR3ci Protein-arginine deiminase type-4
H3R17ci Protein-arginine deiminase type-4
H3R26ci Protein-arginine deiminase type-4
H3R2ci Protein-arginine deiminase type-4
H3R8ci Protein-arginine deiminase type-4
H4R3ci Protein-arginine deiminase type-4