H4K91ub
H4K91 monoubiquitination is essential for protection against DNA damage. Mutation at the H4K91 residue exhibits defective chromatin assembly and increased sensitivity to DNA-damaging agents (PMID: 19818714).
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| Modified variants | Histone H4 |
|---|---|
| Writer/s | E3 ubiquitin-protein ligase DTX3L |
| Eraser/s | |
| Disease associations | No disease associations known for H4K91ub |
Sites of lysine ubiquitination H2AK119ub, H2AK121ub, H2BK120ub, H4K91ub