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H4K91 monoubiquitination is essential for protection against DNA damage. Mutation at the H4K91 residue exhibits defective chromatin assembly and increased sensitivity to DNA-damaging agents (PMID: 19818714).

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H4K91ub infosheet
Modified variants Histone H4
Writer/s E3 ubiquitin-protein ligase DTX3L
Disease associationsNo disease associations known for H4K91ub

Sites of lysine ubiquitination H2AK119ub, H2AK121ub, H2BK120ub, H4K91ub