H2BK120ub
H2B-K120 monoubiquitination is essential for subsequent H3-K4 and H3-K79 methylation and these modifications are marks for active gene transcription (PMID: 16307923). H2BK120ub1 stimulates elongation by RNA polymerase II through chromatin (PMID: 16713563). H2B specific ubiquitin ligase RNF20/hBRE1 which mediates H2BK120ub acts as a putative tumour suppressor through selective regulation of gene expression (PMID: 18832071). CDK9 is reported to regulate gene expression by controlling H2BK120ub1 mark at a global level (PMID: 19575011).
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| Modified variants | Histone H2B type 1-B, Histone H2B type 1-C/E/F/G/I, Histone H2B type 1-D, Histone H2B type 1-H, Histone H2B type 1-J, Histone H2B type 1-K, Histone H2B type 1-L, Histone H2B type 1-M, Histone H2B type 1-N, Histone H2B type 1-O, Histone H2B type 2-E, Histone H2B type 2-F, Histone H2B type 3-B, Histone H2B type F-S |
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| Writer/s | E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase RBX1 |
| Eraser/s | |
| Disease associations | Cancer: All; PMID: 18923072 Neurological disorder: Huntington's disease; PMID: 18400894 |
Sites of lysine ubiquitination H2AK119ub, H2AK121ub, H2BK120ub, H4K91ub