E3 ubiquitin-protein ligase BRE1B
RNF40 belongs to BRE1 family. It is reported to monoubiquitinate histone H2B at lysine 120 in association with RNF20 and is implicated in the regulation of Hox genes (PMID: 16307923).
| UniprotKB Accession | O75150 |
|---|---|
| Alternative Name(s) | 95 kDa retinoblastoma-associated protein (RBP95), RING finger protein 40 |
| Writer for PTM/s | H2BK120ub |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase BRE1B is coded by following 1 non-allelic gene/s |
| Gene name | ring finger protein 40 |
| Gene symbol | RNF40 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0661, RBP95, BRE1B, STARING |
| GeneID | 9810 |
| Chromosomal location | 16p11.2-p1 |
| HGNC | 16867 |
| Unigene | Hs.65238 |
| MIM | 607700 |
| RefSeq mRNA | NM_014771.2 |
| RefSeq Protein | NP_055586.1 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase BRE1B |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1