E3 ubiquitin-protein ligase RING2
RING1B mediates ubiquitination of H2A lysine 119. It is part of a human polycomb repressive complex 1-like (hPRC1L) complex that consists of Ring1, Ring2, Bmi1 and HPH2 (PMID: 15386022). Mel-18 is known to guide RING1B to its substrate (PMID: 17936708). USP7 is reported to modulate the activity of RING1B by deubiquitinating and stabilizing it (PMID: 20800574). RING1B activity seems to be involved in the compaction of DNA and formation of higher order chromatin structure which causes the repression of Hox genes and this function is independent of the histone ubiquitination (PMID: 20471950). It is shown to be phosphorylated by growth factors and signalling molecules like p38 MAPK and ERK1/2 pathways (PMID: 19405034). Ring1b is also responsible for ubiquitination of lysine 121 on H2A.Z. This monoubiquitinylated H2A.Z is associated with inactive X chromosome (PMID: 17636032).
| UniprotKB Accession | Q99496 |
|---|---|
| Alternative Name(s) | Huntingtin-interacting protein 2-interacting protein 3 (HIP2-interacting protein 3), Protein DinG, RING finger protein 1B (RING1b), RING finger protein 2, RING finger protein BAP-1 |
| Writer for PTM/s | H2AK119ub, H2AK121ub |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase RING2 is coded by following 1 non-allelic gene/s |
| Gene name | ring finger protein 2 |
| Gene symbol | RNF2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | BAP-1, BAP1, DING, HIPI3, RING1B, RING2 |
| GeneID | 6045 |
| Chromosomal location | 1q25.3 |
| HGNC | 10061 |
| Unigene | Hs.591490 |
| MIM | 608985 |
| RefSeq mRNA | NM_007212.3 |
| RefSeq Protein | NP_009143.1 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase RING2 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1