E3 ubiquitin-protein ligase DTX3L

BBAP belongs to the Deltex family of proteins. It is known to ubiquitinate histone H4 at lysine 91 position during DNA damage responses. Also loss of H4K91ub is shown to coincide with loss of H4K20 methylation (PMID: 19818714). BBAP is shown to be upregulated in lymphomas that do not respond to chemotherapy. Interferon gamma (IFN-gamma) is reported to regulate the expression of BBAP (PMID: 16809771).

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E3 ubiquitin-protein ligase DTX3L infosheet
UniprotKB AccessionQ8TDB6
Alternative Name(s)B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2 (Rhysin2)
Writer for PTM/s H4K91ub
EC number 6.3.2.-
No. of coding genesE3 ubiquitin-protein ligase DTX3L is coded by following 1 non-allelic gene/s
Gene namedeltex 3-like (Drosophila)
Gene symbolDTX3L
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesBBAP
GeneID151636
Chromosomal location3q21.1
HGNC30323
UnigeneHs.518201
MIM613143
RefSeq mRNANM_138287.3
RefSeq ProteinNP_612144.1
Disease associations
Cancer: Diffuse large B-cell lymphomas; PMID: 16809771

Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1