E3 ubiquitin-protein ligase RBX1
RBX1 belongs to RING-box family. It is known to function in a complex with CUL4 and DDB1. This CUL4-DDB-ROC1 complex is reported to ubiquitinate H3 and H4 histones during UV-induced DNA damage response. This helps in the recruitment of repair factors to the DNA (PMID: 16678110). It is also part of a SWI/SNF chromatin remodelling complex that consists of BAF250, elongin C (Elo C) and cullin 2 (Cul2) and mediates H2B lysine 120 ubiquitination. Reports suggest the role of RBX1 in maintenance of genome integrity (PMID: 21115485).
| UniprotKB Accession | P62877 |
|---|---|
| Alternative Name(s) | Protein ZYP, RING finger protein 75, RING-box protein 1 (Rbx1), Regulator of cullins 1 |
| Writer for PTM/s | H2BK120ub |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase RBX1 is coded by following 1 non-allelic gene/s |
| Gene name | ring-box 1, E3 ubiquitin protein ligase |
| Gene symbol | RBX1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | ROC1, RNF75, BA554C12.1 |
| GeneID | 9978 |
| Chromosomal location | 22q13.2 |
| HGNC | 9928 |
| Unigene | Hs.474949 |
| MIM | 603814 |
| RefSeq mRNA | NM_014248.3 |
| RefSeq Protein | NP_055063.1 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase RBX1 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1