E3 ubiquitin-protein ligase HUWE1
It is a member of TOM1/PTR1 family. Shows in vitro ubiquitination activity for all histone types and is testis specific (PMID: 15767685). Mule is shown to regulate DNA polymerase beta (Pol beta) by ubiquitination and controls base excision repair (PMID: 19713937). HectH9 is shown to ubiquitinate and degrade TopBP1 thus being involved in regulation of cell cycle checkpoint (PMID: 18923429). It is also known to target Rev-erb alpha (heme receptor) for ubiquitination which in turn regulates Clock genes demonstrating its role in circadian cycle (PMID: 20534529).
| UniprotKB Accession | Q7Z6Z7 |
|---|---|
| Alternative Name(s) | ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, Homologous to E6AP carboxyl terminus homologous protein 9 (HectH9), Large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), Upstream regulatory element-binding protein 1 (URE-B1, URE-binding protein 1) |
| Writer for PTM/s | |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase HUWE1 is coded by following 1 non-allelic gene/s |
| Gene name | HECT, UBA and WWE domain containing 1 |
| Gene symbol | HUWE1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | Ib772, KIAA0312, UREB1 |
| GeneID | 10075 |
| Chromosomal location | Xp11.22 |
| HGNC | 30892 |
| Unigene | Hs.136905 |
| MIM | 300697 |
| RefSeq mRNA | NM_031407.4 |
| RefSeq Protein | NP_113584.3 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase HUWE1 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1