E3 ubiquitin-protein ligase RNF168
RNF168 belongs to RNF168 family. Ubiquitinates histone H2A in vitro and in vivo and is responsible for creating 'lysine-63' linked polyubiquitin chains (PMID: 19500350). During DNA damage RNF168 is recruited to the damage foci and helps in recruitment of other factors. Loss of this activity is implicated in RIDDLE syndrome(PMID: 19203578). Recently it has been shown that histone ubiquitination activity of RNF168 is also involved in the transcriptional silencing of DNA regions associated with double strand breaks during DNA damage (PMID: 20550933).
| UniprotKB Accession | Q8IYW5 |
|---|---|
| Alternative Name(s) | RING finger protein 168 |
| Writer for PTM/s | |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase RNF168 is coded by following 1 non-allelic gene/s |
| Gene name | ring finger protein 168 |
| Gene symbol | RNF168 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FLJ35794 |
| GeneID | 165918 |
| Chromosomal location | 3q29 |
| HGNC | 26661 |
| Unigene | Hs.250648 |
| MIM | 612688 |
| RefSeq mRNA | NM_152617.3 |
| RefSeq Protein | NP_689830.2 |
| Disease associations | Immunodeficiency disorder: Riddle syndrome; PMID: 19203578 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1