E3 ubiquitin-protein ligase RNF8
RNF8 belongs to RNF8 family and is responsible for the ubiquitination of H2A and H2A.X at double strand breaks (PMID: 18001824). RNF8 works in association with Ubc13 (E2-conjugation enzyme) to ubiquitinate H2A during nucleotide excision repair as a DNA damage response (PMID: 19797077). 53BP1 is known to elicit DNA damage responses by RNF8 dependent or RNF8 independent manner (PMID: 18337245).
| UniprotKB Accession | O76064 | |
|---|---|---|
| Alternative Name(s) | RING finger protein 8 | |
| Writer for PTM/s | ||
| EC number | 6.3.2.- | |
| No. of coding genes | E3 ubiquitin-protein ligase RNF8 is coded by following 1 non-allelic gene/s | |
| Gene name | ring finger protein 8 | |
| Gene symbol | RNF8 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | KIAA0646 | |
| GeneID | 9025 | |
| Chromosomal location | 6p21.3 | |
| HGNC | 10071 | |
| Unigene | Hs.485278 | |
| MIM | 611685 | |
| RefSeq mRNA | NM_003958.3 | NM_183078.2 |
| RefSeq Protein | NP_003949.1 | NP_898901.1 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase RNF8 | |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1