E3 ubiquitin-protein ligase BRE1A
RNF20 belongs to BRE1 family. It is specific for monoubiquitination of histone H2B at lysine 120. RNF20 is found in a complex with RNF40 and is involved in the regulation of Hox genes (PMID: 16307923). RNF20 is known to regulate gene expression of multiple targets by H2BK120 ubiquitination activity and is supposed to function as a tumour suppressor by modulating cell growth (PMID: 18832071). It is also recruited on double strand breaks and is activated upon ATM mediated phosphorylation (PMID: 21362549).
| UniprotKB Accession | Q5VTR2 |
|---|---|
| Alternative Name(s) | RING finger protein 20 |
| Writer for PTM/s | H2BK120ub |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase BRE1A is coded by following 1 non-allelic gene/s |
| Gene name | ring finger protein 20 |
| Gene symbol | RNF20 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FLJ20382, FLJ11189, KAIA2779, BRE1A, hBRE1, BRE1 |
| GeneID | 56254 |
| Chromosomal location | 9q22 |
| HGNC | 10062 |
| Unigene | Hs.729085 |
| MIM | 607699 |
| RefSeq mRNA | NM_019592.5 |
| RefSeq Protein | NP_062538.5 |
| Disease associations | Cancer: Colorectal cancer; PMID: 18299561 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1