E3 ubiquitin-protein ligase UBR2
UBR2 belongs to the UBR1 family. It is shown to ubiquitinate histone H2A that eventually causes transcriptional silencing (PMID: 20080676).
| UniprotKB Accession | Q8IWV8 |
|---|---|
| Alternative Name(s) | N-recognin-2, Ubiquitin-protein ligase E3-alpha-2, Ubiquitin-protein ligase E3-alpha-II |
| Writer for PTM/s | |
| EC number | 6.3.2.- |
| No. of coding genes | E3 ubiquitin-protein ligase UBR2 is coded by following 1 non-allelic gene/s |
| Gene name | ubiquitin protein ligase E3 component n-recognin 2 |
| Gene symbol | UBR2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | C6orf133 |
| Aliases | bA49A4.1, dJ392M17.3, KIAA0349 |
| GeneID | 23304 |
| Chromosomal location | 6p21.1 |
| HGNC | 21289 |
| Unigene | Hs.529925 |
| MIM | 609134 |
| RefSeq mRNA | NM_015255.2 |
| RefSeq Protein | NP_056070.1 |
| Disease associations | No disease associations known for E3 ubiquitin-protein ligase UBR2 |
Lysine ubiquitinases E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase DTX3L, E3 ubiquitin-protein ligase HUWE1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF8, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UHRF1, V(D)J recombination-activating protein 1