Histone H2A deubiquitinase MYSM1
MYSM1 belongs to the peptidase M67A family. It deubiquitinates H2A at lysine 119 position. MYSM1 contains multiple domains but predominantly catalysis the deubiquitination of H2A. It also facilitates the exclusion of histone H1 and plays an important role in transcriptional regulation (PMID: 17707232).
| UniprotKB Accession | Q5VVJ2 |
|---|---|
| Alternative Name(s) | Myb-like, SWIRM and MPN domain-containing protein 1 |
| Eraser for PTM/s | H2AK119ub |
| EC number | 3.4.19.- |
| No. of coding genes | Histone H2A deubiquitinase MYSM1 is coded by following 1 non-allelic gene/s |
| Gene name | Myb-like, SWIRM and MPN domains 1 |
| Gene symbol | MYSM1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA1915 |
| GeneID | 114803 |
| Chromosomal location | 1p32.1 |
| HGNC | 29401 |
| Unigene | Hs.477495 |
| MIM | 612176 |
| RefSeq mRNA | NM_001085487.1 |
| RefSeq Protein | NP_001078956.1 |
| Disease associations | No disease associations known for Histone H2A deubiquitinase MYSM1 |
Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3