Histone H2A deubiquitinase MYSM1

MYSM1 belongs to the peptidase M67A family. It deubiquitinates H2A at lysine 119 position. MYSM1 contains multiple domains but predominantly catalysis the deubiquitination of H2A. It also facilitates the exclusion of histone H1 and plays an important role in transcriptional regulation (PMID: 17707232).

Download table as Excel
Histone H2A deubiquitinase MYSM1 (2A-DUB) infosheet
UniprotKB AccessionQ5VVJ2
Alternative Name(s)Myb-like, SWIRM and MPN domain-containing protein 1
Eraser for PTM/s H2AK119ub
EC number 3.4.19.-
No. of coding genesHistone H2A deubiquitinase MYSM1 is coded by following 1 non-allelic gene/s
Gene nameMyb-like, SWIRM and MPN domains 1
Gene symbolMYSM1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location1p32.1
RefSeq mRNANM_001085487.1
RefSeq ProteinNP_001078956.1
Disease associationsNo disease associations known for Histone H2A deubiquitinase MYSM1

Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3