Ubiquitin carboxyl-terminal hydrolase 3
USP3 belongs to peptidase C19 family. Deubiquitinates H2Aub and H2Bub marks. Its activity is essential for DNA damage repair and for proper transition from S phase to mitotic phase of the cell cycle (PMID: 17980597).
| UniprotKB Accession | Q9Y6I4 |
|---|---|
| Alternative Name(s) | Deubiquitinating enzyme 3, Ubiquitin thiolesterase 3, Ubiquitin-specific-processing protease 3 |
| Eraser for PTM/s | |
| EC number | 3.4.19.12 |
| No. of coding genes | Ubiquitin carboxyl-terminal hydrolase 3 is coded by following 1 non-allelic gene/s |
| Gene name | ubiquitin specific peptidase 3 |
| Gene symbol | USP3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | |
| GeneID | 9960 |
| Chromosomal location | 15q22.3 |
| HGNC | 12626 |
| Unigene | Hs.458499 |
| MIM | 604728 |
| RefSeq mRNA | NM_006537.2 |
| RefSeq Protein | NP_006528.2 |
| Disease associations | No disease associations known for Ubiquitin carboxyl-terminal hydrolase 3 |
Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3